|
Parameter |
Dual Test |
Triple Test |
Quadruple Test |
|
Timing |
First trimester |
Second trimester |
Second trimester |
|
Components |
1. Beta-hCG 2. PAPP-A
• Nuchal translucency |
1. Beta-hCG 2. AFP 3. uE3 |
1. Beta-hCG 2. AFP 3. uE3 4. Inhibin A |
*PAPP-A (Pregnancy associated plasma protein-A)
Edwards syndrome, Down syndrome and NTD (Neural tube defect)-
|
|
HCG |
uE3 |
MSAFP |
|
Trisomy 18 (Edward syndrome) |
Low |
Low |
Low |
|
Trisomy 21 (Down’s syndrome) |
High |
Low |
Low |
|
Neural tube defect |
- |
- |
High |
• In down’s syndrome - High hCG, Low PAPP-A