• Origin: Derived from neural crest cells, which develop into the adrenal medulla
• Biomarker: Bombesin, Synaptophysin, Chromogranin
• Histopathological finding: Homer-Wright pseudo rosettes
• Diagnosis: Elevated levels of catecholamines or their metabolites (VMA, HVA)
• Opsoclonus myoclonus syndrome (OMS)- A rare paraneoplastic syndrome associated with neuroblastoma, characterized