Vaughan-Williams classification of antiarrhythmic agents

(Mnemonic: SBP Calculate)

1. Sodium channel blocker 

2. Beta blocker 

3. Potassium channel blocker 

4. Calcium channel blocker 

5. Miscellaneous

 

Class

Drug

Class I 

(Sodium

Channel

Blockers)

1a. Potassium channel blocker- 

• Quinidine

• Disopyramide

• Procainamide

 

1b. Potassium channel opener-

(Mnemonic: Phen Melt)

• Phenytoin

• Mexiletine

• Lidocaine

• Tocainide

 

1c. No effect on potassium channel-

• Flecainide

• Propafenone

• Encainide

 

Class II 

(Beta

Blockers)

• Propranolol

• Acebutolol

• Metoprolol

• Esmolol

Class III 

(Potassium

Channel

Blockers)

• Dronedarone

• Amiodarone

• Ibutilide

• Dofetilide

• Sotalol

• Bretyllium

Class IV 

(Calcium

Channel

Blockers)

• Verapamil 

• Diltiazem

Class V 

(Miscellaneous)

(Mnemonic: DAM)

• Digoxin

• Adenosine

• Magnesium sulfate

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