Feature |
Glutathione Peroxidase |
Glutathione Reductase |
Function |
Catalyzes the reduction of hydrogen |
Catalyzes the reduction of oxidized glutathione (GSSG) |
Substrate |
Hydrogen peroxide (H₂O₂) or organic |
Oxidized glutathione (GSSG) and NADPH. |
Cofactor |
Selenium |
FAD (flavin adenine dinucleotide) |
Reaction |
2 GSH + H₂O₂ → GSSG + 2 H₂O |
GSSG + NADPH + H⁺ → 2 GSH + NADP⁺ |
Role in |
Neutralizes harmful peroxides |
Recycles GSH, ensuring its availability |
Clinical |
Deficiency can lead to increased |
Impaired activity can disrupt redox homeostasis, |