Sorbitol pathway

In hyperglycemic condition (like diabetes) glycolysis enzyme hexokinase becomes saturated and the excess glucose enter into polyol / sorbitol pathway.

 

Sorbitol pathway (Polyol pathway)- It is a two step process.

Step 1. Glucose convert into sorbitol / polyol by aldose reductase.

Step 2. Sorbitol convert into fructose by sorbitol / polyol dehydrogenase.
 

Arpit gupta, from TCML Team

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