Collagen types and their primary locations in the body:
|
Type of collagen |
Location |
|
Type 1 (Most abundant & widely distributed) |
Non cartilagenous connective tissue: 1. Bone 2. Tendon 3. Ligament 4. Cornea 5. Skin |
|
Type 2 |
1. Cartilage 2. Vitreous humor of eye |
|
Type 3 |
Extensible connective tissue: 1. Lung 2. Blood vessels 3. Skin |
|
Type 4 |
Basement membrane |
|
Type 5 |
Often with tissue containing Type I collagen |
|
Type 6 |
Muscle |
|
Type 7 |
Dermal epidermal junction |
|
Feature |
Collagen |
|
Alport syndrome |
Type IV collagen (Alpha-5 chain) |
|
Goodpasture syndrome |
Type IV collagen (Alpha-3 chain) |
|
Osteogenesis imperfecta (Brittle bone disease) |
Type I collagen |