Disorders of copper metabolism

Wilson disease

Menke disease

1. Autosomal recessive

1. X linked recessive

2. Mutation in the ATP7B gene

2. Mutation in the ATP7A gene

3. Defective copper excretion
(Copper overload in body)

3. Impaired copper absorption
(Copper deficiency in body)

 

NOTE: Wilson disease involves excess copper, while Menke involves copper deficiency.

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