Oxygen-hemoglobin dissociation curve

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Affection 

for oxygen

Decreased affinity

Increased affinity

Hb-oxygen 

binding

Oxygen is less tightly bound;

more readily released

Oxygen is more tightly bound; 

less readily released 

Causes

- Increased CO2

- Decreased CO2

 

- Increased temperature

- Decreased temperature

 

- Decreased pH (acidosis)

- Increased pH (alkalosis)

 

- Increased 2,3-BPG

- Decreased 2,-BPG

Implication

Enhanced oxygen delivery

to tissues

Reduced oxygen delivery

to tissues

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