Opioids

Receptor

Morphine

Naloxone

Naltrexone

mu

Agonist

(strong)

Antagonists

(strong)

Antagonists

(strong)

kappa

Agonist

(weak)

Antagonists

(medium)

Antagonists

(strong)

delta

Agonist

(weak)

Antagonists

(weak)

Antagonists

(weak)

 

NOTE: Naloxone is a competitive antagonist at mu-opioid receptors, which are the primary sites of action for opioid analgesics. By blocking these receptors, naloxone can reverse the effects of opioid overdose.

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