Antibiotics that inhibit bacterial protein synthesis target the ribosomal subunits (30s & 50s).
Binding to the 30s ribosomal subunit- (Mnemonic: AMT)
• Aminoglycosides: Streptomycin
• Tetracycline: Doxycycline
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Topical Aminoglycoside |
Systemic Aminoglycoside |
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• Neomycin • Framycetin
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• Gentamicin • Amikacin • Tobramycin • Streptomycin • Kanamycin
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Binding to the 50s ribosomal subunit- (Mnemonic: Chlo CML)
• Chloramphenicol: cause Gray man syndrome
• Clindamycin: it disrupt normal gut flora (increase risk of clostridium difficile infection)
• Macrolides (Erythromycin, Azithromycin)
• Linezolid
Clostridium difficile infection (CDI) treatment-
• DOC before: Vancomycin (oral)
• DOC Now: Fidaxomicin (oral)- Macrolide, inhibit sigma-subunit of RNA polymerase