Alcohol withdrawal

Detoxification

(prevent withdrawal symptoms)

Maintenance

(prevent relapse
/ maintain abstinance)

1st DOC: BZD (it depress the pt) +
Thiamine (Vit B1)

2nd DOC: Benzodiazepines (BZD)

Start with high dose
& dose reduction 20% per day.

Pharmacological agent- 

1. Deterrent / Aversive agent: 

Disulfiram- inhibit aldehyde
dehydrogenase 

2. Anti craving agents:
(Love by pt, Love by Dr.)

• Acamprosate 

• Naltrexone 

• Ondansetron 

• Topiramate 

• Baclofen

• Fluoxetine 

• Gabapentine

Note: Only Acamprosate & Naltexone
are FDA approved.

BZD

Drug

Short acting 

Lorazepam 

Long acting 

• Chlordiazepoxide

• Diazepam