Platelet function disorder

Disorder

Receptor Defect

Platelet Adhesion

Platelet Aggregation

Glanzmann
Thrombasthenia

GP IIb/IIIa defect

Normal adhesion

Impaired aggregation due to
defective fibrinogen binding

Bernard-Soulier
Syndrome

GP Ib defect

Impaired adhesion to
von Willebrand factor (vWF)

• Normal aggregation with
ADP, epinephrine

• Impaired with ristocetin

von Willebrand
Disease

von Willebrand factor (vWF)
deficiency or defect

Impaired adhesion
to subendothelial

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