Iron transport

 

Transporter

Location

Function

DMT1

(Divalent Metal

Transporter 1)

Apical membrane

of enterocytes

Transports Fe²⁺ from the 

intestinal lumen into enterocytes

Cytochrome b

(Cytb)

Apical membrane

of enterocytes

Reduces Fe³⁺ to Fe²⁺, facilitating

its transport by DMT1

Ferroportin

(FPN)

Basolateral membrane

of enterocytes

Exports Fe²⁺ from enterocytes

into the bloodstream

Hephaestin

Basolateral membrane

of enterocytes

Oxidizes Fe²⁺ to Fe³⁺ to facilitate its

binding to transferrin in the bloodstream

 

Arpit gupta (from TCML Team)

 

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