Aspect |
c-ANCA (Cytoplasmic) |
p-ANCA (Perinuclear) |
Target |
Proteinase 3 (PR3) |
Myeloperoxidase (MPO) |
Staining |
Cytoplasmic (diffuse granular staining) |
Perinuclear (around the nucleus) |
Associated Diseases |
- Granulomatosis with polyangiitis (GPA) |
- Microscopic polyangiitis (MPA) - Eosinophilic granulomatosis with polyangiitis (EGPA) - Ulcerative collitis |
Clinical |
Upper and lower respiratory tract + renal involvement |
Renal + systemic vasculitis symptoms |
Diagnosis |
ELISA for PR3 antibodies |
ELISA for MPO antibodies |