Anti-Neutrophil Cytoplasmic Antibodies (ANCA)

c-ANCA (Cytoplasmic)

Aspect

p-ANCA (Perinuclear)

Proteinase 3 (PR3)

Target

Antigen

Myeloperoxidase (MPO)

Cytoplasmic (diffuse

granular staining)

Staining

Pattern

Perinuclear (around

the nucleus)

• Granulomatosis with

polyangiitis (GPA)

Associated

Diseases

• Microscopic polyangiitis (MPA)

• Eosinophilic granulomatosis with
polyangiitis (EGPA)
/ Churg-Strauss syndrome

• Ulcerative collitis (UC)

• Primary sclerosing cholangitis
(PSC)

Upper and lower respiratory

tract + renal involvement

Clinical

Features

Renal + systemic vasculitis
symptom

ELISA for PR3 antibodies

Diagnosis

ELISA for MPO antibodies